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Opioids could also result in worsening of pre-existing central sleep apnoea (see part 4.eight). Concomitant use of oxycodone and sedative medicines for example benzodiazepines or similar drugs may perhaps lead to sedation, respiratory despair, coma and Loss of life. Because of these dangers, concomitant prescribing Using these sedative medicines mu

Drug withdrawal syndrome may perhaps happen upon abrupt cessation of therapy or dose reduction. Whenever a individual now not calls for therapy, it is actually a good idea to taper the dose little by little to minimise signs or symptoms of withdrawal. Tapering from the higher dose may possibly take weeks to months.Sufferers may additionally dietary